Precision-Formulated AM/PM Packs
$200.00
Clinician-Built Supplement Systems
Precision
supplementation.
Built around
your biology.
Not another supplement brand. A data-driven protocol layer — mapped to your biomarkers, refined by a physician, delivered as precision AM/PM daily packs.
LegitScript Certified
Physician-Reviewed
Lab-Adaptive
AM/PM Packs
ASPN Member Profile — Stack Intelligence
Live
BIOMARKER FLAGS — DRIVING STACK hover any marker
hs-CRP
2.8 mg/L
Elevated
Free T
6.1 pg/mL
Low
Vitamin D
22 ng/mL
Deficient
Magnesium
1.6 mg/dL
Watch
HRV (Oura)
34 ms
Below Baseline
ASPN OS — MAPPED STACK
AM
Vitamin D3 5,000 IU
Omega-3 3g EPA/DHA
Zinc Picolinate
Tongkat Ali
PM
Magnesium Glycinate
Ashwagandha
Turmeric + Bioperine
NAC
JS
Dr. James Sutton · ASPN Health Strategist M.D.
Stack prioritizes hs-CRP and Vitamin D as primary gaps. Free T support added — reviewed at the week 8–10 retest.
Active
THE MISSING LINK
Your protocols are only
Your protocols are only
as effective as the
nutrients behind them.
Every compound in your ASPN protocol has upstream nutritional dependencies. Without the right foundation, you're running advanced clinical interventions on a depleted system.
40–60%reduction in peptide efficacy from Zinc deficiency alone
25–35%lower GH pulse amplitude without adequate Magnesium
Select a protocol
Semaglutide
GLP-1 Receptor Agonist — Weight & Metabolic
As caloric intake drops dramatically on semaglutide, micronutrient density collapses within weeks. The fatigue, muscle loss, and GI distress most patients attribute to the drug are largely deficiency states — not side effects. A coordinated supplement foundation changes the entire experience.
Without supportMuscle catabolism, B12 depletion, persistent GI discomfort, energy crash
With ASPN stackPreserved lean mass, sustained energy, improved GI tolerance, optimized composition
Critical Requirements
B12 + IronRate-limiting cofactors for energy. Depleted within 4–6 weeks of food restriction. Primary driver of GLP-1 fatigue.
MagnesiumInsulin sensitivity and metabolic enzyme activity. Drops rapidly with reduced intake — impairing the metabolic improvements semaglutide is driving.
Vitamin D3Immune function, mood, and metabolic health. Frequently depleted during caloric restriction.
Fiber + Digestive EnzymesReduced gut motility is the primary GI complaint. Psyllium and enzymes address this directly.
→ GLP-1 Support Stack
Tirzepatide
GIP + GLP-1 Dual Agonist — Weight & Metabolic
Tirzepatide produces more aggressive appetite suppression than semaglutide — which means more severe micronutrient depletion, faster. The dual GIP/GLP-1 action amplifies insulin sensitivity, making magnesium status especially critical for avoiding metabolic stall.
Without supportAccelerated muscle loss, electrolyte imbalance, metabolic plateau, mood instability
With ASPN stackLean mass preserved, electrolytes balanced, metabolic rate sustained, mood stable
Critical Requirements
Magnesium + ChromiumTirzepatide's insulin-sensitizing action requires magnesium for receptor sensitivity. Both drop rapidly with reduced food intake.
B12 + MultivitaminStronger appetite suppression means steeper depletion. A comprehensive baseline is essential from week one.
Fiber + Digestive EnzymesSupports optimal nutrient extraction from dramatically reduced meals.
→ GLP-1 Support Stack
NAD+
Mitochondrial Coenzyme — Cellular Energy & Longevity
NAD+ synthesis is B-vitamin dependent at every step. Running NAD+ therapy without addressing B-complex status is like flooding an engine with no oil. The upstream pathway must be supported for the intervention to reach its ceiling.
Without supportBlunted energy response, limited sirtuin activation, suboptimal mitochondrial output
With ASPN stackFull NAD+ synthesis pathway supported, enhanced cellular energy, optimal sirtuin response
Critical Requirements
B-Complex (Niacin, B6, B12, Folate)NAD+ is synthesized via a B-vitamin-dependent pathway. Deficiency in any rate-limits NAD+ production regardless of supplementation.
MagnesiumCofactor in ATP production that NAD+ enables. Magnesium deficiency caps the cellular energy ceiling NAD+ is trying to raise.
Omega-3 (EPA/DHA)Mitochondrial membrane composition determines energy transfer efficiency. Omega-3s build better mitochondrial membranes.
→ Foundational Five + NeuroRestore
Glutathione
Master Antioxidant — Detoxification & Cellular Protection
Glutathione synthesis requires three amino acid precursors plus B6, folate, and selenium as cofactors. Without upstream support, IV or oral glutathione has limited staying power as the body's recycling system remains depleted.
Without supportRapid depletion post-treatment, limited cellular protection, ongoing oxidative burden
With ASPN stackSustained levels, enhanced recycling via NAC, optimized detox pathway function
Critical Requirements
NAC (N-Acetyl Cysteine)Rate-limiting amino acid precursor for glutathione synthesis. Most evidence-based method for sustaining intracellular levels between IV treatments.
B6 + Methylfolate + B12Cofactors in synthesis pathway. MTHFR variants — common in our member population — further impair this and require methylated B-vitamin support.
Vitamin CRegenerates oxidized glutathione back to active form. Without it, glutathione is consumed faster than the body can recycle it.
→ Inflammation & Recovery Stack
Sermorelin
GHRH Analogue — Growth Hormone Secretagogue
Sermorelin works by amplifying natural GH pulses during deep sleep. Magnesium deficiency directly impairs delta-wave sleep architecture, reducing the amplitude of GH pulses that sermorelin is trying to enhance. You're paying for a signal boost on a compromised signal.
Without supportBlunted GH pulses, limited IGF-1 response, reduced body composition impact
With ASPN stackDeep sleep optimized, GH pulse amplitude maximized, IGF-1 response enhanced
Critical Requirements
Magnesium L-ThreonateThe only form with demonstrated BBB penetration. Directly supports delta-wave sleep — the exact window in which sermorelin's GH pulses occur. Single highest-impact variable for secretagogue outcomes.
ZincSupports IGF-1 receptor signaling — the downstream pathway through which GH pulses create tissue and body composition effects.
Vitamin D3GH and Vitamin D share overlapping receptor pathways. Low D3 limits GH receptor sensitivity and reduces the body composition response.
→ NeuroRestore + Foundational Five
Testosterone / TRT
Androgen Replacement — Hormonal Optimization
Vitamin D3 is a direct cofactor in testosterone biosynthesis — deficiency is one of the most common reversible causes of low T. Starting TRT without correcting nutritional deficiencies means supplementing a hormone that the receptor system isn't equipped to fully utilize.
Without supportLimited free T utilization, aromatization excess, sleep impairment, suboptimal body composition
With ASPN stackMaximized free T utilization, estrogen balanced, recovery optimized, full receptor sensitivity
Critical Requirements
Vitamin D3 (5,000 IU)Direct cofactor in testicular testosterone synthesis. D3 repletion alone raises free T significantly in deficient individuals.
Zinc PicolinateAromatase inhibition requires adequate zinc. Low zinc accelerates estrogen conversion and reduces the free T benefit of TRT.
Magnesium GlycinateBinds SHBG, freeing more testosterone for bioavailability. Also essential for sleep quality and androgen receptor sensitivity.
→ Men's TRT Support Stack
HRT (Women)
Estrogen / Progesterone — Hormonal Balance & Protection
HRT provides the hormones — but whether they metabolize safely depends entirely on liver detoxification capacity and methylation status. Estrogen metabolites that aren't cleared properly drive symptoms and risk. The nutritional environment determines whether HRT is protective or problematic.
Without supportPoor estrogen clearance, elevated inflammatory metabolites, mood instability, bone density gaps
With ASPN stackClean estrogen metabolism, mood stability, bone protection optimized, inflammatory burden reduced
Critical Requirements
DIM + Calcium D-GlucarateDIM drives estrogen into the protective 2-hydroxyestrone pathway. Calcium D-Glucarate prevents reabsorption of conjugated estrogens in the gut.
Methylfolate (5-MTHF)MTHFR variants impair methylation of estrogen metabolites. Methylfolate bypasses this block and ensures proper estrogen detoxification.
Vitamin D3 + K2Bone density protection is primary in HRT. D3 and K2 direct calcium into bone rather than soft tissue — HRT without them leaves significant protection on the table.
→ Women's HRT Support Stack
Enclomiphene
SERM — Endogenous Testosterone Restoration
Enclomiphene restores the HPG axis signal to produce LH and FSH, which drive endogenous testosterone production. The quality of that response depends entirely on raw materials: zinc, vitamin D, and magnesium. Without them, the HPG axis is signaling a factory with no supplies.
Without supportHPG axis restored but testosterone synthesis limited by nutrient deficiency
With ASPN stackFull testosterone synthesis capacity unlocked, LH response maximized, free T elevated
Critical Requirements
Zinc PicolinateRequired by the enzymes converting cholesterol to testosterone in Leydig cells. Enclomiphene restores the LH signal; zinc ensures cells can respond to it.
Vitamin D3D3 receptors are expressed in Leydig cells — the same cells enclomiphene stimulates. Low D3 directly limits testosterone output regardless of LH signaling.
Magnesium + AshwagandhaMagnesium reduces SHBG, increasing free T bioavailability. Ashwagandha reduces cortisol which directly suppresses LH signaling through the HPG axis.
→ Men's TRT Support Stack
Your ASPN protocol likely includes several of these. Your supplement stack should account for all of them.
Map My Nutritional Foundation
THE ASPN JOURNEY
Your biology, tracked in real time.
Your biology, tracked in real time.
Your stack, refined every month.
Not a one-time purchase. An ongoing data relationship between your biology and your protocol — with weekly ESR monitoring, wearable feedback, and physician-reviewed adjustments.
Day 1
Blood Panel + Intake
Comprehensive biomarker panel — inflammation markers, hormones, metabolic, vitamin status, ApoB, hs-CRP, ESR. Paired with symptom intake and wearable data upload from Apple Watch, Oura, or Garmin.
hs-CRPFree TApoBVitamin DHRVESR
01
02
Day 3–5
Physician Stack Review
Your ASPN Health Strategist reviews every biomarker, cross-references your active protocol compounds, and maps a precise supplement foundation. Every selection is explained and documented.
JS
Dr. James Sutton · M.D.
"Vitamin D at 22 ng/mL is your highest-impact gap. Zinc to support TRT androgen axis. Turmeric + NAC for hs-CRP priority."
Week 1
AM/PM Packs Arrive
Precision-dosed morning and evening packs delivered. No bottles. No counting. Each compound timed to your circadian biology — AM for energy and cognition, PM for recovery, sleep, and hormonal restoration.
AMD3 · Zinc · Omega-3 · Multivitamin
PMMagnesium · Ashwagandha · Turmeric · NAC
03
04
Weeks 2–4 · Ongoing
Wearable + Weekly ESR Testing
HRV, sleep stages, and recovery scores stream continuously. Weekly ESR testing tracks systemic inflammation in real time — a faster signal than quarterly panels. Your strategist monitors and flags anomalies before they become problems.
ESR Trend↓ Wk 2
HRV↑ +8ms
Sleep Score74 / 100
Recovery68%
Week 6
Inflammation Retest + Stack Review
First full biomarker recheck — hs-CRP, ESR, key hormones and vitamins. Results reviewed against six weeks of continuous wearable trends. Stack adjusted if the data calls for it.
hs-CRP retest
ESR retest
Vitamin D retest
Free T — trending
05
06
Month 3
Full Panel + Protocol Refinement
Complete biomarker review. Stack refined based on what's improved, what's stalled, and what the next protocol phase demands. The system evolves with your biology — not a static product.
hs-CRP review
Free T review
HRV review
Phase 2 stack added
THE FULL SYSTEM
Every stack. Every signal.
Every stack. Every signal.
Every category.
Select a category. Each card shows biomarker triggers, protocol pairings, and expected outcomes.
Foundational Health
Foundational Five
The non-negotiable nutritional baseline. Five clinician-selected compounds addressing the deficits that undermine every other intervention — regardless of goals, genetics, or protocol.
Best forEveryone. The starting point before any advanced protocol.
Works withEvery ASPN protocol. Stacks beneath all categories.
Deficiency signals
Low Vitamin DMagnesium DeficitLow ZincOmega-3 InsufficiencyInside the Stack
Essential Multivitaminenergy, immunity & recovery baseline
Vitamin D3hormone precursor, bone & immune function
Zinc Picolinatetestosterone synthesis & aromatase regulation
Magnesium Malatesleep, insulin sensitivity & cortisol
Omega-3 (EPA/DHA)systemic inflammation & membrane quality
Expected OutcomeNutritional gaps are rechecked at follow-up labs.
Cognitive Performance
ASPN NeuroPeak
Sharpens focus, amplifies working memory, and sustains cognitive output. Built for executives, athletes, and anyone operating at the edge of mental capacity.
Best forFocus, mental clarity, cognitive endurance
Pairs withPhysician-directed cognitive compounds, nasal NAD+
Biomarker triggers
Low AcetylcholineBrain FogPoor FocusInside the Stack
Alpha-GPCacetylcholine synthesis & neurotransmission
Rhodiola Roseastress resilience & cognitive recovery
L-Tyrosinedopamine precursor & focus under load
Acetyl-L-Carnitinemitochondrial energy in neurons
Expected OutcomeFocus and cognitive routines are reviewed with your care team.
Neuroinflammation + Sleep
ASPN NeuroRestore
Targets neuroinflammation, sleep architecture, and cognitive recovery. For elevated stress load, disrupted sleep, or ongoing brain recovery deficits.
Best forSleep disruption, neuroinflammation, high cortisol
Pairs withNAD+, NeuroPath protocol
Biomarker triggers
Elevated hs-CRPLow HRVHigh CortisolInside the Stack
Omega-3neuroinflammation & cognitive recovery
Turmeric (Curcumin)brain inflammation & BBB protection
Magtein (Mg L-Threonate)memory, learning & delta-wave sleep
L-Theaninecalm focus, anxiety & sleep onset
AshwagandhaHPA axis regulation & cortisol reduction
Apigeninsleep quality without morning grogginess
Expected OutcomeSleep quality and HRV are tracked. Neuroinflammation markers are reviewed at 6-week labs.
Inflammation Resolution
Inflammation & Recovery Stack
Systemic inflammation is the root driver behind most performance deficits, hormonal dysfunction, and metabolic disruption. This stack hits inflammatory pathways across joints, gut, liver, and immune systems simultaneously.
Best forElevated hs-CRP, joint pain, slow post-training recovery, gut inflammation
Pairs withAnti-inflammatory nutrition protocol, physician-directed recovery compounds
Primary biomarker triggers
hs-CRP >1.5ESR ElevatedJoint DiscomfortGut PermeabilityInside the Stack
Turmeric (Curcumin + Bioperine®)joints, muscle soreness & gut lining
NAC (N-Acetyl Cysteine)glutathione, detox & cellular repair
TUDCAliver health & gut integrity
Boswellia Serratajoint mobility & connective tissue
Ginger Root Extractdigestion & inflammatory cytokines
Omega-3 (EPA/DHA)systemic inflammation & joint lubrication
Expected Outcomehs-CRP is rechecked at follow-up labs. Joint mobility and recovery are tracked.
Men's Hormonal Support
Men's TRT Support Stack
Addresses the nutritional gaps testosterone optimization creates. Supports free testosterone, hormonal balance, and recovery for men on or approaching TRT.
Best forTRT, low T, hormonal optimization, libido, body composition
Pairs withTestosterone Cypionate, HCG, DHEA, Enclomiphene
Biomarker triggers
Low Free TLow ZincHigh CortisolInside the Stack
Zinc Picolinatetestosterone & aromatase regulation
Magnesium Glycinatesleep, recovery & androgen receptor sensitivity
Vitamin D3testosterone biosynthesis cofactor
Tongkat Alifree testosterone & libido support
Omega-3cardiovascular & inflammation
Ashwagandhacortisol reduction & anabolic balance
Expected OutcomeFree T support is reviewed at follow-up labs.
Women's Hormonal Support
Women's HRT Support Stack
Supports estrogen metabolism, hormonal balance, mood stability, and bone density for women navigating perimenopause, post-HRT, or hormonal optimization.
Best forHRT, perimenopause, estrogen balance, bone density
Pairs withEstrogen, Progesterone, DHEA, physician protocols
Biomarker triggers
Estrogen ImbalanceLow Vitamin DMood DisruptionInside the Stack
Magnesium Glycinatemood, sleep & enzyme activity
Vitamin D3 + K2bone density & calcium metabolism
Methylfolate (5-MTHF)estrogen detox & mood regulation
DIM2-hydroxyestrone pathway support
Omega-3 (EPA/DHA)inflammation & hormonal health
Calcium D-Glucarateestrogen clearance & liver detox
Expected OutcomeMood, sleep and estrogen metabolism are reviewed at follow-up labs.
GLP-1 / Metabolic Support
GLP-1 Support Stack
Precision-designed for critical nutritional gaps that GLP-1 therapy creates. As caloric intake decreases, micronutrient density must increase — this stack ensures metabolic and digestive function supports healthy recomposition, not just weight loss.
Best forSemaglutide, Tirzepatide — anyone in active GLP-1 therapy
Pairs withAll GLP-1 variants, anti-inflammatory nutrition protocol
Protocol triggers
Active GLP-1 TherapyReduced IntakeMicronutrient GapsInside the Stack
Comprehensive Multivitaminmicronutrient baseline during reduced intake
Vitamin D3immune function & metabolic health
Magnesiuminsulin sensitivity, sleep & muscle preservation
Iron & B12energy & red blood cell production
Fiber (Psyllium)satiety, gut motility & microbiome health
Digestive Enzymes + Probioticnutrient absorption & GI comfort
Expected OutcomeEnergy and micronutrient status are reviewed at 6-week labs.
Precision Delivery
Your daily AM/PM pack.
Mapped to your biomarkers.
Mapped to your biomarkers.
30-Day Supply
The ASPN Supplement Stack.
Built around your biology.
Built around your biology.
NOT SURE WHERE TO START?
We'll map the right stack
We'll map the right stack
to your labs and goals.
30 minutes with an ASPN Health Strategist gives you a mapped starting point based on your actual biomarkers — no guesswork, no generic recommendations.
0avg. days on protocol
0% protocol adherence
0% biomarker improvement
6–8 wkavg. time to first result
QUALITY YOU CAN VERIFY
Clinician-built. Third-party tested.
Clinician-built. Third-party tested.
Protocol-integrated.
Third-Party Tested
Every ingredient independently verified for purity, potency, and label accuracy. Certificate of Analysis available. No proprietary blends obscuring clinical dosing.
COA AvailablePhysician-Supervised
Every stack designed by physicians and clinical health strategists. Dosed to clinical standards, not retail margins or mass-market assumptions.
MD-ReviewedCircadian-Timed
AM formulas support energy, cognition, and metabolic function. PM formulas support recovery, sleep, and hormonal restoration — timed to your biology.
Circadian-AlignedProtocol-Integrated
Supplements are the nutritional foundation every clinical intervention builds on. Not standalone products — a clinical operating layer inside your full protocol.
LegitScript Certified
BEGIN YOUR PROTOCOL
Stop guessing.
Stop guessing.
Start measuring.
ASPN supplement stacks are built around your biology, reviewed by a physician, and refined every month as your data changes. This is your clinical operating system for daily nutritional support.